2012-1-20(Friday)
The Senri Life Science Seminar; "Cutting-edge of Autophagy Study"
Date: January 20th (Friday), 2012 9:30-17:10
Place: Life Hall at Senri Life Science Center (5F), Osaka
Participation fee: Free (300 capacity)
Sponsor: Senri Life Science Foundation


 Autophagy is a bulk degradation system of cellular constituents. Since identification of genes autophagy has attracted a good deal of attention for biology and medical researchers. Protein turnover via autophagy is so fundamental function of eukaryotic cells, now almost everyday important findings appear, showing autophagy is relevant to many physiological events and diseases. However, there are many questions are remained to answer to understand a whole process of autophagy and its roles at a molecular level.
 This symposium aims to introduce and discuss about recent progress in autophagy by leading scientists of this field from Japan and abroad.

==================================
Agenda
Programs Speaker
Opening address Tadamitsu Kishimoto
(President of Senri Life Science Foundation)
Introduction Yoshinori Ohsumi
(Tokyo Institute or Technology)
New approaches toward the elucidation of molecular mechanisms of autophagy Hitoshi Nakatogawa
(Tokyo Institute of Technology)
Insights into membrane dynamics in selective and non-selective autophagy Tamotsu Yoshimori
(Osaka University)
Selective autophagy mediated by autophagic adapter proteins Terje Johansen
(University of Tromsoe, Norway)
The mechanism of secretory autophagosomes mediated unconventional protein secretion Vivek Malhotra
(Center for Genomic Regulation, Barcelona, Spain)
Parkinson's disease (PD) and autophagy: Two familial PD gene products, PINK1 and Parkin, cooperate to identify, label and clear damaged mitochondria Tatsuhiro Shibata
(Project Leader, Cancer Genomics Project National Cancer Center)
Neuronal autophagy and its therapeutic potential for neurodegenerative disease Steven Finkbeiner
(University of California, San Francisco, USA)
Autophagy regulation in cells and whole organisms Noboru Mizushima
(Tokyo Medical and Dental University)
Closing remarks Keiji Tanaka
(The Tokyo Metropolitan Institute of Medical Science)




2011-9-1 (Thursday)∼ 2 (Friday)
MEI-Center Symposium "Symposium 2011 on Antisense, Gene, and Delivery "


Symposium 2011 on Antisense, Gene, and Delivery
Date: September 1 (Thurs.) ∼ 2 (Fri.), 2011
Venue: Osaka University, Convention Center
Participation fee: Charged

==================================
Agenda
Programs Speaker
Special Lecture:
Molecular design of a nucleic acid drug and
RNA-imaging
Akira Murakami (Prof., Kyoto
Institute of Technology)
Gene and siRNA delivery with a supramolecular
nanodevice
Kazunori Kataoka (Prof., the
University of Tokyo)
Invited Lecture:
Cell-to-cell delivery of miRNA by exosome
 
Takahiro Ochiya (National Cancer
Center Research Institute)
Impaire expression of miRNA in cancer, and its
therapeutic application
Yukihiro Akao (Gifu University)
 
Current state and expectation of antisense and
siRNA medicinesMakoto Koizumi (Daiichi Sankyo
Makoto Koizumi (Daiichi Sankyo
Co., Ltd.)
Specific transport of siRNA HSP47 to astrocyte by
VA coupled liposome, and its fusion effect on
fibrous tissue
Yoshiro Niitsu (Sapporo Medical
University)
 
New strategy of anticancer gene therapy:
Immunotherapy by microbial protein gene
Yoshiyuki Koyama (OTSUMA
Women's University)
Development of application of
ultrasonic-responsive bubble liposome to delivery
system for nucleic acid and gene
Youichi Negishi (Tokyo University
of Pharmacy and Life Sciences)
 




2011-4-20 (Wednesday):
The 62th MTR Seminar " Immune response regulation with regulatory T cell " by Shimon Sakaguchi (PhD, WPI Osaka University, IFReC, Experimental Immunology)


Date: 18:00-19:00, Wednesday 20 April, 2011 Venue: Osaka University Hospital

Foxp3+CD25+CD4+regulatory T cell existing in normal individual is crucial to maintain immunological self-tolerance and homeostasis, and its quantitative/ qualitative abnormality become direct cause of various autoimmune diseases or inflammatory disorders.

For instance, in human gene abnormality of Foxp3, not only autoimmune diseases and inflammatory enterocolitis but also serious allergic disorders occur in high frequency.
Therefore, various immune disorders can be prevented and treated by using endogenous regulatory T cells.

Moreover, a long-term transplantation immune tolerance for the implanted organ is derivable by strengthening the regulatory T cell. On the other hand, an effective tumor immune response is inducible by the removal or the functional operation of the regulatory T cell.

In this lecture, the pathological-physiological immune response regulation with the regulatory T cell will be discussed.



2011-1-21 (Friday):
The Senri Life Science Seminar; "The tissue construction with the polarity-control-mediated cells, and the disease state by its abnormality"


Date: 10:00-17:00, January 21 (Friday), 2011
Place: Life Hall at Senri Life Science Center (5F), Osaka
Participation fee: Free (300 capacity)
Sponsor: Senri Life Science Foundation

Acquisition of polarity with cell is an important characteristic that the cell shows in various life phenomena. For instance, peculiar forms and functions seen in differentiated epithelial cell and neuronal cell, etc. are based on the cellular polarization. Moreover, especially in course of development, the cellular morphology changes to generate the tissue and the organ by combination of polarization and depolarization.
In this case, it is necessary for polarization of many cells to be adjusted spatially and temporally in an artful way. On the contrary, a destruction of the tissue polarity once established takes part in the malignant alteration of cancer. Though the molecular mechanism of the polarity determination in top-bottom axis of an individual cell and anterior-posterior axis on its movement has been clarified so far, the understanding how the polarized cell forms the tissue is still insufficient.

In this seminar, the latest study results will be summarized by front-line researchers, and the relation between the morphogenesis and the polarity will be discussed from the molecular level to the individual level.

==================================
Agenda
Programs Speaker
OpeningAkira Kikuchi (Osaka University)
The role of intercellular contact and cellular polarity Hippo-route in early embryonic developmentHiroshi Sasaki (Kumamoto University)
The cell polarity analysis by using imaging technologyEtsuki Kiyokawa (Kyoto University)
On abnormality of tissue construction and the disease state due to abnormality of the polarized transport of the cellAkihiro Harada (Osaka University)
Epithelial morphogenesis via cellular polarization and depolarizationAkira Kikuchi (Osaka University)
Interaction of normal epithelial cell and mutant cell -Aiming at the development of the new cancer therapy-Yasuyuki Fujita (Hokkaido University)
Polarity control of nerve tissue and the disease state due to its abnormalityKozo Kaibuchi (Nagoya University)
Closing remarksGen Yamada (Kumamoto University)




2010-10-22 (Friday)
The Senri Life Science Seminar; "A New Life Image Being Clarified by The Next Generation's Sequencer" -Toward understanding of the life at a molecular level-


Date: 10:00-17:00, October 22 (Friday), 2010
Place: Life Hall at Senri Life Science Center (5F), Osaka
Participation fee: Free (300 capacity)
Sponsor: Senri Life Science Foundation

The next generation's sequencer of various types with marvelous data production capacity has appeared one after another. As a result, the revolution was brought in the way of life science research based with the Central Dogma. It is not an exaggeration to say that the way to truly understand the life at a molecular level has been opened.
In this seminar, the current status of the next generation's sequencer will be summarized, and then some examples of the genome width analysis for the omics-data obtained in a variety of species will be presented.

==================================
Agenda
Programs Speaker
Opening RemarksYoshihide Hayashizaki (Director, RIKEN Omics Science Center)
Current Development Status and Use of the Next Generation's SequencerYoshihide Hayashizaki (Director, RIKEN Omics Science Center)
From the Genome to the Meta GenomeKen Krokawa (Prof. Tokyo Institute of Technology, The School and the Graduate School of Bioscience and Biotechnology
Diversity of Rice Plant Being Clarified with High-throughput SequencingTakeshi Itoh (Manager, National Institute of Agrobiological Sciences (NIAS))
New Twist of Transcriptome Analysis with the Next Generation's SequencerHarukazu Suzukizuki ( Project Director ,RIKEN Omics Science Center)
New Chromosome Study Being Led by Next Generation's SequencerKatsuhiko Shirahige (Prof. Institute of Molecular and Cellular Biosciences,
The University of Tokyo
New Understanding of the Cancer Being Brought by Whole Genome
Sequencing
Tatsuhiro Shibata (Project Leader, Cancer Genomics Project
National Cancer Center)
Closing RemarksHarukazu Suzuki ( Project Director , RIKEN Omics Science Center)




2010-9-17 (Monday) to 9-18:
IPR Seminar: Disorder and Protein Science in Membrane Dynamics


Date : 13:00 - 18:40 Friday, September,17 2010
             9:00 - 12:10 Saturday, September,18 2010
Place : Main Hall (1F) at The Institute for Protein Research (IPR) , Osaka University
Participation fee: Free

==================================
Agenda
Programs Speaker
13:00 - 18:40 Program - September,17
Welcome RemarksToshiharu Hase (Director of IPR, Osaka University)
Address from Organizing CommitteeYuji Goto (IPR, Osaka University)
Session 1; Bacterial and Viral Infections
Enhancement mechanism of cell adhesion using a host factor Annexin A2 of Escherichia coliToru Tobe (School of Medicine, Osaka University)
Perception of viral multiplication and antiviral innate immune reactionTakashi Fujita (Institute for Virus Research, Kyoto University)
Analysis of yeast Prion-like factor KIL-d which introduces mutation into double-stranded RNA virusGenjiro Suzuki (RIKEN BSI)
Session 2; Molecular Mechanism in Membrane Dynamics (Membrane Regulation)
Shape control mechanism in biomembrane with lipid-binding domainToshiki Itoh (School of Medicine, Kobe University)
Activation mechanism for membrane fusion in fertilizationNaokazu Inoue (Research Institute for Microbial Diseases, Osaka University)
Morphological change of lipid membrane by OPA1 and its role for mitochondrial membrane fusionTadato(?) Ban (School of Medicine, Fukui University)
Session 3; Prion / Amyloid (Coagulation Mechanism)
An oligomeric intermediate that induces high infectious amyloid of yeast prion Sup35Yumiko Ohashi (RIKEN BSI)
Analysis of intramolecular interaction of normal type Prion protein by fragment(?) molecular orbital methodTakeshi Ishikawa (Center for Emerging Infectious Diseases, Gifu University)
Direct observation of amyloid formation reaction by fluorescent microscopyHisashi Yagi (IPR, Osaka University)

Programs Speaker
9:00 - 12:10 Program - September,18
Session 4; Molecular Mechanism in Membrane Dynamics (Autophagy)
The regulation mechanism of membrane dynamics in autophagyTakeshi Noda (FBS, Osaka University)
Structural basis for selective autophagyNobuo Noda (Pharmaceutical Sciences, Hokkaido University)
Session 5; Prion/Amyloid (Disorder Mechanism)
Intracellular transport of abnormal type Prion protein in cells persistently-infected with PrionMotohiro Horiuchi (Veterivary Medicine, Hokkaido University)
Application of in vitro amplification technique for abnormal Prion protein to cerebrospinal fluid diagnosis for Prion diseaseNoriyuki Nishida (Biomedical Sciences, Nagasaki University)
The molecular mechanism in defective synthesis of Prion protein and disease formationNaomi (?) Hachiya (Tokyo Medical University)
Concluding RemarksKazuo Kuwata (Center for Emerging Infectious Diseases, Gifu University)



2010-7-20 (Tuesday):
The 55th MTR Seminar " Purification of cardiomyocyte and development of its efficient transplant procedure aiming at realization of heart regenerative medicine " by Fumiyuki Hattori (PhD, Cardiology, Keio University School of Medicine; Researcher of Asubio Pharma Co., Ltd.)


Date: 18:00-19:00, Tuesday 20 July, 2010 Venue: Osaka University Hospital

The mammals do not have ability to regenerate a heart by oneself. Hattori and his colleagues make a large amount of cardiomyocyte by using the ES-cell and iPS-cell, and are aiming at the achievement of new medical treatment that replenishes failing heart with this. For this purpose, it is necessary to develop a purification method of the cardiomyocyte and its efficient transplant procedure.

They avoided the use of the gene modification method in order to prompt clinical application, and took the strategy applying the characteristic of the cardiomyocyte. First, they succeeded in the high purity refinement of the cardiomyocyte by using the characteristic that the myocardium had mitochondria more than other cells. Next, they clarified the reason why transplanted cardiomyocyte could not be firmly established in the organization. In addition, they succeeded in dramatic improvement of the survival rate after a transplant by making and transplanting "cardiac muscle ball" through application of the characteristic of an immature cardiomyocyte, in comparison with discrete transplant. They believe that these methods contribute to the heart regenerative medicine in the future.



2010-6-21 (Tuesday)
"Current Status and Future Prospect of Biomedicines "
("Protein-Mall KANSAI" -5th Information Exchange Seminar-)
The latest approaches in the R&D of biomedicines such as the)
nucleic acid medicine, the protein medicine, and the glyco-drug will )
be presented in this seminar.


Date : 13:30-17:30, Tuesday, Jun 21, 2010
Venue: Life Hall at Senri Life Science Center (5F), Osaka
Subject: "Current Status and Future Prospect of Biomedicines "

==================================
Agenda
Programs Speaker
Molding Power of RNA and Drug DiscoveryYoshikazu Nakamura, Professor, The Institute of Medical Science
Development of the Decoy Oligonucleotide Medicine Targeting Transcription Factor NF-κBShinnya Ihara, Manager, AnGes MG, Inc.
The Latest Mass Imaging Analysis / Possibility of Application to Paraffin SectionYutaka Aoki, Researcher, SHIMADZU CORPORATION
Development of Biomedicines by Drug-exploratory Proteomics and its StandardizationYasuo Tsutsumi , Professor, School of Pharmaceutical Sciences (Toxicology), Osaka University
Current Status and Future Expectation of the Glyco-drug DiscoveryTaniguchi Naoyuki, Professor, The Institute of Scientific and Industrial Research (ISIR)




2010-6-14 (Monday)
IPR Seminar: Cooperation in Protein Science between Asian and Pacific Countries
Organizers : Fumio Arisaka (Tokyo Inst. of Tech.), Haruki Nakamura (IPR), Yuji Goto
(IPR)


Date : June 14th (Mon), 2010, 9:00 - 17:00
Place : Institute for Protein Research (1F Lecture Hall), Osaka University
Participation fee: Free

==================================
Agenda
Programs Speaker
Welcome remarks : 9:00Toshiharu Hase (Director of IPR)
Session 1 : 9:10 - 10:10
Aims of this IPR SeminarYuji Goto (IPR)
Synchrotron radiation beam line for macromolecular assembly crystallography at SPring-8Atsushi Nakagawa (IPR)
Protein informatics studies for structural features in protein-protein interactionsHaruki Nakamura (IPR)
Session 2 : 10:25 - 11:40
Unfolded proteins, proteins design and protein aggregationDaniel Raleigh (President of the Protein Society; State Univ. of New York, Stony Brook, USA)
NMR investigation on structure-function relationship of intrinsically unfolded proteins (IUPs)Kyou-Hoon Han (Korea Res. Inst. of Biosci. and Biotech., Korea)
Malaria surface proteins as vaccine and drug targetsRaymond S. Norton (Walter and Eliza Hall Inst. of Med. Res., Australia)
Session 3 : 13:00 - 14:35
Identification of the fatty-acid binding site in the anti-tumor complex of α-lactalbumin by 920-MHz NMR spectroscopyKunihiro Kuwajima (President of PSSJ; Okazaki Inst. of Integrative Biosci., Japan)
Homo-oligomerization as a common way for proteins to modulate their activitiesZengyi Chang (Secretary-General of 2011 APPA Conference; Peking Univ., China)
Folding and assembly of human HspB4 (αB-crystallin)Ch Mohan Rao (Centre for Cellular & Molecular Biology, India)
Conformational stability plays a role in amyloid formation: a story of Aβ in Alzheimer's diseaseYun-Ru Chen (Academia Sinica, Taiwan)
Session 4 : 14:50 - 17:05
A story for proline for two decadesYoung Kee Kang (Chungbuk National Univ., Korea)
Structural studies of the interaction of rice β-glycosidases with their substrates and reaction intermediatesJisnuson Svasti (Mahidol Univ., Thailand) and James R. Ketudat Cairns (Suranaree Univ. of Tech., Thailand)
Protein structure prediction by global optimation and its applicationJooyoung Lee (Korea Inst. for Advanced Study, Korea)
Mechanism of the strict sequential assembly of the tail wedge of bacteriophage T4Fumio Arisaka (Tokyo Inst. of Tech., Japan)
Open discussion 
Reception : 17:00-18:30




2010-3-4 (Thursday):
"Protein-Mall KANSAI" -4th Information Exchange Seminar-
An enterprise, a university, and a research organization having a strength and interest in protein-related research and development have accumulated in Kansai area around "Saito" Life Science Park and North Osaka.
"Protein-Mall KANSAI" was constructed as industry-academic-government cooperation project by making the best use of this accumulation. It holds the information exchange seminar on May 4, 2010, about the research achievements in universities and research organizations, as well as about situation of the development front in enterprises. This seminar is held as a chapter of the itemized discussion of "Current Status and Future Prospect of the Peptide Drugs (general remarks)" held in January, 2010.


Date : 13:30-17:30, Thursday, March 4, 2010
Venue: Life Hall at Senri Life Science Center (5F), Osaka
Subject: "Current Status and Future Prospect of Peptide Drugs (on details)"


==================================
Agenda
Programs Speaker
WT1 peptide vaccine immunotherapy to cancerYusuke Oji, Professor, Osaka University Graduate School of Medicine
From the discovery of new peptide in living body to the clinical applicationKenji Kangawa, Director General, National Cardiovascular Center Research Institute
New direction of designed protein drugsMitsuyoshi Ueda, Professor, Graduate School of Agriculture, Kyoto University
Drug development study of SUN11031 (human ghrelin)Mayumi Furuya, Group Leader, Asubio Pharma Co., Ltd.



2010-1-18 (Monday):
The Senri Life Science Seminar; "2010 Senri Life Science International Symposium on "Future Outcome of Stem Cell Research Today"


Date : 10:00-17:00, January 18 (Monday), 2010
Place: Life Hall at Senri Life Science Center (5F), Osaka
Participation fee: Free (300 capacity)
Sponsor: Senri Life Science Foundation

The Generation of human pluripotent stem cells, such as ES cells and iPS cells, has great impact on scientific and medical fields. These cells will provide unprecedented tools for medical research, drug discovery, toxicology, and cell replacement therapy. In this symposium, we would like to discuss recent advances, challenges, and future perspectives of pluripotent stem cells. In this symposium, the scientists at the forefront of this field will talk about the future.


==================================
Agenda
Programs Speaker
Induction of pluripotency by defined factors.Shinya Yamanaka(Kyoto University)
Genetic modification and differentiation of
human embryonic stem cells-creating tools for regenerative medicine.
Andrew Elefanty(Monash University)
Directed differentiation of pluripotent stem cells.Gordon Keller(University Health Network)
Motor neuron progenitor cell replacement
therapy for spinal cord injury and disease.
Hans S. Keirstead(University of California at Irvine)
iPS cell technologies for studies on
CNS-regeneration and disease mechanisms.
Hideyuki Okano(Keio University)
Using stem cells and reprogramming to
study disease.
Kevin Eggan(Harvard University)



2009-11-27 (Monday) to 11-28:
IPR Seminar: Signal transduction of active oxygen


Date : 13:30-18:05 Fryday, November.27, 2009
        9:00-12:20 Saturday, November.28, 2009
Place: Main Hall (1F) at The Institute for Protein Research (IPR) , Osaka Univ.
Participation fee: Free

==================================
Agenda
Programs Speaker
13:30-18:05 Program - November.27
Opening Hiroaki Miki(IPR, Osaka University)
The mechanism of active oxygen generation by phagocyteHideki Sumimoto (Graduate School of Medical Sciences, Kyushu University)
Molecular mechanism of active oxygen generation in plant immunityKou Shimamoto(The Graduate School of Biological Sciences, NAIST)
The chemical biology of thiol-reactive ligandKoji Uchida (School of Agricultural Sciences, Nagoya University)
Post-translational modification caused by electrophilic reagent, and factors regulating this processYoshito Kumagai (The Graduate School of Comprehensive Human Sciences, University of Tsukuba)
New post-translational modification and electrophilic signal by active oxygenTakaaki Akaike(School of Medicine, Kumamoto University)
Stress-responsive MAPK route by stress granulation and apoptotic controlMutsuhiro Takekawa(Research Institute of Environmental Medicine, Nagoya University)
The cell death with adaptor molecules participating in TNF signal and inflammatory controlHiroyasu Nakano (School of Medicine, Juntendo University)
Activity-regulation mechanism of ASK family caused by stress and pathological conditionHidenori Ichijo ( Graduate School of Pharmaceutical Sciences, the University of Tokyo )

Programs Speaker
9:00-12:20 Program - November.28
Development of a large variety of ROS- and RNS-selective fluorescent probes based on rational molecular designYasuteru Urano (Graduate School of Pharmaceutical Sciences,The University of Tokyo)
Signal transduction control by protein nitrosylationAkio Matsumoto (Faculty of Pharmaceutical Sciences ,Chiba University)
Endoplasmic reticulum function failure and neuronal cell death through nitrosation stressTakashi Uehara (Faculty of Pharmaceutical Sciences, Hokkaido University)
Signal transduction controlled by redox modification of proteinHiroaki MIKI (IPR, Osaka University)
Signal transduction of nucleic acid oxidation and cell deathYusaku Nakabeppu (Medical Institute of Bioregulation Department ofImmunobiology and Neuroscience, Kyushu University)
Molecular and structural bases for Nrf2-Keap1 environment-responsive functionMasayuki Yamamoto (Graduate School of Medicine Department of Medical Sciences, Tohoku University)
Closing remarksTakaaki Akaike (Faculty of Medical and Pharmaceutical Sciences, Kumamoto University)



2009-11-26 (Thurthday):
OBI Seminar; "Chemical synapses at atomic resolution: Structure and mechanism of transmitter-gated ion channels" by Dr.Eric Gouaux, Senior Scientist, Vollum Institute, Oregon Health and Science University


Date: Nov 26,2009 (Thu) 16:00-17:30
Lecturer: Dr.Eric Gouaux
Senior Scientist, Vollum Institute, Oregon Health and Science University

Subjects: "Chemical synapses at atomic resolution: Structure and mechanism of transmitter-gated ion channels"
Place: OBI Conferece Room



2009-11-6 (Friday):
The Senri Life Science Seminar; "The Next Generation of Brain Research"


Date : 10:00-17:00, November 6 (Friday), 2009
Place: Life Hall at Senri Life Science Center (5F), Osaka
Participation fee: Free (300 capacity)
Sponsor: Senri Life Science Foundation

The brain is an object of the great interest for not only the scientist but also the general people as the last frontier of the human race.

The brain research is approached from various fields like physiology, anatomy, developmental biology, molecular biology, biochemistry, computational science and psychology, etc., and the sense of values diverges into many branches now. However, the awareness of the issues is shared in the point assumed to want to solve the mystery of the work of the brain.

This simple interest is the fun of the brain study. On the other hand, social requests for the science are increasing inside and outside the country, and the aspect is no exception in the brain research.

In this symposium, world outstanding brain researchers of our country will present their latest research developments, and participants will be able to grasp the future prospect through the analysis of the present state and the discussion.


==================================
Agenda
Programs Speaker
Opening Tsunehiko Yamamoto (The Graduate School of Frontier Biosciences Osaka)
Habenular Nucleus; Search for the Switch Board of the Action and the MemoryHitoshi Okamoto (RIKEN Brain Science Institute (BSI))
Fluctuation and Vital FunctionToshio Yanagida (Nanobiology Laboratories, The GraduateSchool of Frontier Biosciences (FBS) Osaka University)
Synapse Transmission Adjustment Caused by Endogenous Cannabinoid and Brain FunctionMasanobu Kano (Laboratory of Integrative Physiology,The University of Tokyo School of Medicine)
Way to the Mechanism of Human Higher-order Brain Function Keiji Tanaka (RIKEN Brain Science Institute (BSI))
Information Control Mechanism of Neural CircuitShigetada Nakanishi (Osaka Bioscience Institute)
Panel DiscussionMasanobu Kano,Toshio Yanagida,
Hitoshi Okamoto
Keiji Tanaka, Shigetada Nakanishi
Moderator; Fujio Murakami
Closing remarksFujio Murakami (The Graduate School of Frontier Biosciences Osaka University)



2009-11-5 (Thurthday):
OBI Seminar; "Cilia dysfunction in syndromic and non-syndromic retinal degeneration" by Professor Anand Swaroop,Senior Investigator and Chief, Neurobiology-Neurodegeneration & Repair Laboratory,National Eye Institute,National Institutes of Health


Date: Nov 5,2009 (Thu) 12:00-13:00
Lecturer: Professor Anand Swaroop
Senior Investigator and Chief, Neurobiology-Neurodegeneration & Repair Laboratory, National Eye Institute,
National Institutes of Health

Subjects: "Cilia dysfunction in syndromic and non-syndromic retinal degeneration"
Place: OBI Conferece Room



2009-10-26 (Monday):
The 48th MTR Seminar "Cell and tissue culture design for the transplant --Technologies that cultivate and evaluate the cell and tissue-- " by Prof. Masahiro KINO-OKA (Dr. Eng.)(Associate Professor, Dept. of Orthopedic Surgery, Osaka City University Graduated School of Medicine)


Date: 18:00-19:00, Monday 26, October, 2009
Venue: Osaka University Hospital

A cell/tissue culture premising the transplant is the process that is important from the viewpoint of production, and the process and quality control for safety and the efficacy is indispensable in order to supply a final cell/tissue product with uniform and stable quality. As for evaluation technologies, those concerning safety have been constructed considerably up to now, but those concerning efficacy is still insufficient.

In this lecture, the planar culture design enabling cell morphology control, the automation of cultivation process, and the stereological evaluation of the cultured tissues for the chondrocyte, myoblast and mesenchymal stem cell will be presented widely from the culture process control to the quality control. The contribution of chemical engineering to these technology developments will also be discussed.



2009-9-9 (Wednesday):
The 48th MTR Seminar "Reproduction of Articular Cartilage by the Cell Transplant- Mainly on the bone marrow mesenchymal cell (BMMC) transplantation" by Prof.Shigeyuki Wakitani (Dept. of Orthopedic Surgery, Osaka City University Graduated School of Medicine)


Date: 18:00-19:00, Wednesday 9, September, 2009
Venue: Osaka University Hospital

The articular cartilage reproduction by the cell transplant is one of the treatment methods that have been clinically applied since the earliest time. The autologous chondrocytes transplant was reported in rabbits in 1989, and became the tissue regeneration technological method that FDA authorized first in the orthopedics field of the world in 1997. Since then the treatment has been executed in more than 20,000 cases all over the world. However, its availability is being still controverted.

At first, Wakitani and his colleagues had made an attempt on allogeneic chondrocytes transplant, but they abandoned its approach because of the difficulty for cell collection in Japan. Afterwards, they started the research on the bone marrow mesenchymal cell (BMMC) transplantation, and tried the clinical application in advance of the world in 1998, but it has not come to be generalized yet. In this lecture, their recent research results will be presented together with their efforts for the generalization (industrialization).



2009-8-25 (Tuesday):
The Senri Life Science Seminar; "Cancer Stem Cell Research Leading to Clinical Application"


Date : 10:00-17:00, August 25 (Tuesday), 2009
Place: Life Hall at Senri Life Science Center (5F), Osaka
Participation fee: Free (300 capacity)
Sponsor: Senri Life Science Foundation

The cancer stem cell plays an important role to generation, the treatment resistance, the recurrence, and the metastasis, etc. of the malignant tumor. The cancer stem cell research with the possibility of connecting directly with the clinical application has been preceded in the hematopoietic organ tumor, and currently the verification is advanced aggressively also as for a solid tumor. In this seminar, the trend of the cancer stem cell research on a solid tumor will be summarized first, followed by presentations of updated research results leading to the clinical application in the near future, which help young researchers to improve their skills.

Coordinator;
Masaki Mori (Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University)
Tetsuya Taga (Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University)

==================================
Agenda
Programs Speaker
Overview Masaki Mori (Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University)
The cancer stem cell in digestive organ cancerHideshi Ishii (Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University)
Masaki Mori (Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University)
Trend of cancer stem cell research in hepato-biliary-pancreatic organsHideki Taniguchi (Department of Regenerative Medicine, Yokohama City University, School of Medicine)
Characterization analysis of glioma stem cellToru Kondo (Laboratory for Cell Lineage Modulation, the Center for Developmental Biology, RIKEN)
Searching for the cancer cell regulation from molecular bases of both proliferating ability and pluripotency of the neural stem cellTetsuya Taga (Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University)
Epigenetics of cancer stem cell and function of polycomb geneAtsushi Iwama (Department of Cellular and Molecular Medicine, Graduate School of Medical and Pharmaceutical Sciences, Chiba University)
Difference between stem cell and cancer stem cellToshio Suda (Laboratory for Difference of Cell Differentiation, School of Medicine, Keio University)
Closing remarksTetsuya Taga (Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University)



2009-7-13 (Monday) to 7-14:
IPR Seminar: Clarification and control of Prion phenomenon based on its protein structures


Date : 13:00-18:00 Monday, July.13, 2009
        9:00-16:00 Tuesday, July.14, 2009
Place: Main Hall (1F) at The Institute for Protein Research (IPR) , Osaka Univ.
Participation fee: Free

==================================
Agenda

Program - July.13
Overview
Session1"Folding and miss-Folding"
Session2"Clarification and Control of Prion phenomenon, Part1"
Welcome Reception

Program - July.14
Session3"Clarification and Control of Prion phenomenon, Part2"
Session4"Establishment of New Dogma in Life Science (New Therapy and Technology) "
Closing remarks



2009-5-25 (Monday):
IFReC, The International Symposium; "Immune Regulation: Present and Future"


The symposium that invites a famous immunology researcher in every country in the world will be held by co-sponsoring the Kishimoto fundation with the Osaka University immunology frontier research center. Moreover, the poster session for the young researcher will be done.

Date: May 25-27, 2009
- Venue: Osaka International Convention Center (OSAKA, Japan)
- Download the symposium poster.
- Download the schedule.

Organizers:
Shizuo Akira (Director of IFReC),
Toshio Hirano, Hitoshi Kikutani, Tadamitsu Kishimoto,
WPI Immunology Frontier Research Center, Osaka University (WPI-IFReC),
Kishimoto Foundation

Contact:
Immunology Frontier Research Center (IFReC), Osaka University
E-mail: ifrec-sympo@ifrec.osaka-u.ac.jp



2009-5-22 (Friday):
The Senri Life Science Seminar;"Use of integrated medical data base to personalized medical treatment"


Date : 10:00-17:00 Friday, May.22, 2009
Place: Life Hall at Senri Life Science Center (5F), Osaka
Participation fee: Free (300 capacity)
Sponsor: Senri Life Science Foundation
e-mail: sng@senri-life.or.jp

The development of comprehensive molecular information (OMICS) including the genomeis remarkable in recent years, and the construction of integrated medical database involving not only clinical information but also molecular information is starting. Such medical database is expected to promote personalized medical treatment that suits each patient, and to encourage predictive medical care that forecasts accurately the medicines’ efficacy or the disease trajectory. In this seminar, the current status, the trend, and the future potential of integrated medical database will be discussed.
Coordinator;
Hiroshi Tanaka (Prof. General Director, Information Center for Medical Sciences, Tokyo Medical and Dental University)
Tsuneaki Sakata(Prof. Cyber Media Center, Osaka University)

==================================
Agenda
Programs Speaker
Overview Tsuneaki Sakata(Prof. Cyber Media Center, Osaka University)
Integrated medical database based on OMICS information Hiroshi Tanaka (Prof. General Director, Information Center for Medical Sciences, Tokyo Medical and Dental University)
The strategy of integrated database in life science and personalized medicine Takashi Gojobori (Prof. The National Institute of Genetics (NIG))
Treatment information database: a trial in circulatory disease area Ryozo Nagai (Prof. Graduate School of Medicine and Faculty of Medicine, University of Tokyo)
Current status of human genome mutation database and Human Variome Project Shinsei Minoshima (Prof. Photon Medical Research Center, The Hamamatsu University School of Medicine )
Personalized medicine-related research groups supported by RIKEN SciNesTetsuro Toyota (Director, Bioinformatics And Systems Engineering division, RIKEN)
Medical information database and data warehouseYasutomi Kinosada (Prof. The United Graduate School of Drug Discovery and Medical Information Sciences,Gifu University)
Panel Discussion: Integrated medical data base and personalized medical treatment Takashi Gojobori,Ryozo Nagai,Shinsei Minoshima,Tetsuro Toyota,Yasutomi Kinosada, Moderator;Hiroshi Tanaka
Closing remarksHiroshi Tanaka (Prof. General Director, Information Center for Medical Sciences, Tokyo Medical and Dental University)



2009-04-17 (Friday):
The Senri Life Science Seminar;"Epigenetics: the strategy that manages genome and uses it"


Date : 10:00-16:10 Friday, Apr.17, 2009
Place: Life Hall at Senri Life Science Center (5F), Osaka
Participation fee: Free (300 capacity)
Sponsor: Senri Life Science Foundation
e-mail: sng@senri-life.or.jp

Epigenetics is an advanced use strategy of the genome that the eukaryote has generated. It has been understood that epigenetics' mechanism involves non-coding RNA besides various chromatins modification. Moreover, the epigenome research has accelerated at a dash by introduction of the latest technologies including the next generation's sequencer. Knowing epigenome and using it are indispensable for making, differentiation induction, and quality control of the stem cell, as well as diagnosis or treatment of cancer and clarification of the lifestyle disease.

==================================
Agenda
Programs Speaker
Overview Sasaki Hiroyuki (Prof. Division of Human Genetics, National Institute of Genetics)
Small RNA and retro element suppressionSatomi Miyakawa (JST PRESTO resercher,The Graduate School of Frontier Biosciences Osaka University)
Genome quality control and reprogramming of the stem cellTakashi Shinohara (Prof. Molecular Genetics, Kyoto University Graduate School of Medicine)
Large-scale epigenome analysis and diseaseHiroyuki Aburatani (Prof. Research Center for Advanced Science and Technology(RCAST),The University of Tokyo)
DNA methylation of tumor suppressor gene and RNAiMinoru Toyata (Prof. Biochemistry, Sapporo Medical University)
Metabolic syndrome and epigenetics Juro Sakai (Prof. Research Center for Advanced Science and Technology(RCAST),The University of Tokyo)
Closing remarksYoichi Shinkai (Prof. Department of Cell Biology, Institute for Virus Research, Kyoto University )



2009-4-16 (Thurthday):
The 47th MTR Seminar "Cell transplant treatment for cardiac failure-Especially, research on relevant paracrine effect-" by Prof. Ken Suzuki(Translational Cardiovascular Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary, University of London, UK)


Date: 18:00-19:00, Thurthday 16, April, 2009
Venue: Osaka University Hospital

The cell transplantation is extremely promising as a new treatment for cardiac failure, and its clinical application is pushed forward in each country.However, further basic studies in various respects are necessary and indispensable so that this treatment approach may succeed in the future.
Suzuki and his colleagues, in order to develop more safe and effective strategy in this approach, have been clarifying dynamic state and changes of transplanted cell and its direct/indirect effects on the cardiac muscle from various points of view.
In this lecture, their recent works, especially on paracrine effects caused by the cell transplantation, will be presented in detail.



2009-04-15 (Wednesday):
SAITO Symposium "Aiming at Overcoming the Lifestyle Diseases"


Date : 10:00-18:00 Wednesday, Apr.15, 2009
Place: Life Hall at Senri Life Science Center (5F), Osaka
Participation fee: Free (300 capacity)
Sponsor: Saito Life Science Park Location Promotion Conference
e-mail: sympo_regist@saito.tv

Purpose:
1. Summarizing the global trend of biomarker research, functional food and supplement as measures against lifestyle diseases (metabolic syndrome, fatigue, and stress, etc.) .
2. Promoting business partnering between enterprises located at Saito/LSP.

==================================
Agenda
Programs Speaker
10:00-10:05
Welcome and Introduction
Yutaka Takasugi, M.D. & Ph.D. (Director General, Osaka Prefectural Hospital Organization)
10:05-11:00
Keynote Lecture: Metabolic Syndrome and Visceral Fat
Yuji Matsuzawa, M.D.& Ph.D. (Director General, SUMITOMO HOSPITAL)
11:00-11:45
Special Lecture: Lifestyle Diseases, the Current Status and Countermeasures in the United Statest
Mitsunori Ono, M.D.& Ph.D. (Founder and CSO of Betal)
11:45-12:30
Special Lecture: Quercetin as a Component of Novel Nutraceutical Formulations and Its Role in Disease Prevention and Treatment
Thomas C Lines, (CEO, Quercegen Pharma, LLC)
12:30-13:30 (Lunch Time) 
13:30-14:00
The Role of Herbal Medicines in Lifestyle Diseases
Yoshitaka Ohta (Director, Alps Pharmaceutical Ind. Co., Ltd.)
14:00-14:30
(under planning)
Osami Kajimoto, M.D. & Ph.D. (Director, Soiken Holdings Co., Ltd.)
14:30-15:00
(under planning)
Ushio Nakanishi, Ph.D. (Director, MG Pharma, Inc.)
15:00-15:15 (Coffee Break) 
15:15-15:45
The Analysis of the Nuclear Receptor Related to a Lifestyle Disease for Functional Foods Development
Akihiro Yamaguchi (R&D Executive, Japan Food Research Laboratories)
15:45-16:15
Food Functionality Evaluation Panel with the Cultured Cell
Hiroyuki Fukuda (Manager, Saito Proteomics Analysis Center, Theravalues Corporation
16:15-16:30 (Coffee Break) 
16:30-17:00
(under planning)
Yoshimi Niwano (Manager, Successful Products Development Division, Sunny Health Holdings Co.,Ltd.
17:00-17:30
(under planning)
Aiko Sakai (Leader, New Products Development Team, PIP-Fujimoto Co,.LTD.)
17:30-18:00
(under planning)
Alsace Bio Valley
18:00-18:05 Closing Remarks 
18:15-19:45 (Welcome Reception)at 6F Senri Hall, Attendance fee: 2,000yen



2009-03-16 (Monday):
The Computation Mechanism of the Cell: from ES Cells to the Neuron


Date : 10:00-17:30 Monday, Mar.16, 2009
Place: Life Hall at Senri Life Science Center (5F), Osaka
Participation fee: Free (300 capacity)
Sponsor: Senri Life Science Foundation
e-mail: sng@senri-life.or.jp

The brain science and the cellular biology have accomplished their original development even though giving influences with each other. In this seminar, through a lot of research on these fields, universality and diversity in the computational capability and its implementation mechanism will be discussed, exceeding the big difference of a physical scale of the "Brain" and the "Cell".

Especially,
1) How wise is the "Brain" and the "Cell" respectively?
2) Does the "Cell" have memory and learning rule like the "Brain" ?
3) The contribution of the genetic program to the learning ability of the "Brain", etc. are discussed thoroughly from viewpoints of molecular/cellular biology, and the brain science.

Coordinators:
Hiroki Ueda(Laboratory for Systems Biology, RIKEN Center for Developmental Biology )
Kenji Doya (Neural Computation Unit, Okinawa Institute of Science and Technology)


==================================
Agenda
Programs Speaker
Overview Hiroki Ueda (Laboratory for Systems Biology, RIKEN Center for Developmental Biology)
ES Cell:Loss and versatility of cell memory Hitoshi Niwa (Laboratory for Pluripotent Stem Cell Studies, RIKEN Center for Developmental Biology)
Genome memory via non-coding RNA in cerebral developmentTakuya Imamura (Laboratory for Biodiversity (Global COE Project), Kyoto University )
The circadian clock and calendar as an environment-prediction and sensory system of the cellHiroki Ueda (Laboratory for Systems Biology, RIKEN Center for Developmental Biology)
Learning by plasticity of the spike timing dependent synapseShinya Kuroda(Systems Biology, Department of Biochemistry & Biophysics the School of Science, the University of Tokyo.)
The signal transduction from synapse to nucleus, and from nucleus to synapseHaruhiko Bito(Department of Neurochemistry, University of Tokyo Graduate School of Medicine)
Computational theory of "Behavior Learning" and plasticity mechanism of the cellKenji Doya(Neural Computation Unit, Okinawa Institute of Science and Technology
Panel DiscussionPanelist:Hitoshi Niwa, Takuya Imamura, Shinya Kuroda, Haruhiko Bito      Moderator: Hiroki Ueda & Kenji Doya
Closing remarksKenji Doya(Neural Computation Unit, Okinawa Institute of Science and Technology



2009-02-19 (Wednesday):
The 45th MTR Seminar " Regeneration therapy based on underlying mechanism of heart failure" by Prof. Issei Komuro, Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine.


Date: 18:00-19:00, February 19, 2009
Venue: Osaka University Hospital

  Cardiac hypertrophy occurs as a compensatory response to various stresses. However, collapse of the compensation causes heart failure. Prof. Komuro and colleagues have clarified that the cardiac angiogenesis is crucially involved in the adaptive mechanism of cardiac hypertrophy and that an accumulation of tumor suppressor gene p53 is essential for the transition from cardiac hypertrophy to the heart failure (Sano, et al. Nature 2007)

  They treated about 80 patients with peripheral arterial obstruction by angiogenesis therapy using peripheral blood mononuclear cells, and found effectiveness in over 70 percent of them. They are planning to apply the therapy to patients with cardiac failure.

  In addition, they identified IGFBP-4 as a potent enhancer of cardiomyocyte differentiation (Zhu, et al., Nature, 2008). IGFBP-4 played a role indispensable to cardiomyocyte differentiation and even to cardiogenesis by down regulating wnt signal . The possibility of its promoting effect on cardiac regeneration is currently under investigation.




2009-02-16 (Monday):
Symposium 2009 / The Biomedical Cluster Kansai


The Knowledge Cluster Initiative (started by The Ministry of Education, Culture, Sports, Science and Technology (MEXT) in 2007) is promoting "Drug Discovery", "Regenerative Medicine", and "Prevention of the Lifestyle Diseases". In this Symposium, research progress obtained so far will be presented.

Date: 10:00-16:50 Monday, Feb.16, 2009
Venue: Life Hall and Conference room 501/502/503 at Senri Life Science Center (5 F), Osaka
Participation fee: Free (140 capacity)
Sponsor: Biomedical Cluster Kansai
Senri Life Science Foundation
The Foundation for Biomedical Research and Innovation (FBRI)
e-mail: cluster-11@senri-life.or.jp


Program:
Two invited lectures and research papers (8 oral and 27 poster presentations), etc.

More details: http://www.ibri-kobe.org/event/pdf/2009/seika.pdf


Invited lectures:
"Preparation and application of a cancer stem cell model"
Hideyuki Saya (Professor, Institute for Advanced Medical Research Keio University School of Medicine)

"An approach for establishment of basic technologies related to transplant therapy with regenerated cardiomyocyte "
Keiichi Fukuda(Professor, The Graduate School of Medicine, Keio University)



2009-2-12,13 (Thursday,Friday):
The 2nd International Symposium of WPI-IFReC "Dynamics of Immune Responses" will be held in February, 2009.


Poster Image is here.


Date: Feb. 12-13, 2009
Time: 9:00 am- (registration: 8:30 am-)
Place: Icho-kaikan, Suita campus, Osaka University



2009-2-10 (Tuesday):
Welcome to "The International Bio-ventures Meeting in Saito"


"The International Bio-ventures Meeting in Saito" will be held at Saito LSP with participation of overseas venture 8 companies by Bio Business Station (NPO), in cooperation with JETRO and the Osaka Prefecture Bio-Headquarter. A lot of Bio-ventures in Saito will also participate at lunch time party. It will be a good opportunity for participants to collect and exchange the information and to expand the network.

Date: 10:00-15:00, Tuesday, Feb. 10
Place: Saito Bio-hills Center main hall, Saito LSP, Osaka
Sponcer: Bio Business Station (NPO), JETRO/Osaka, Osaka Prefecture
Fee: Free
Application: bbstation@osaka.cci.or.jp

==================================
Agenda

10:00-10:40
"Current Status of Bio-industries in Northern Osaka and Kansai Bio-Cluster"

Ryuichi Morishita (Professor, Department of Geriatric Medicine, Osaka University Medical School, Director of AnGes MG, Inc. )

10:40-11:30
"Short Presentations by Overseas Bio-ventures "

IMAXIO (France)
Glycode (France)  www.glycode.fr
Insilico Biotechnology (Germany)
Hannovar Clinical Trial Center (Germany)
ASCENION (Germany)
Inson Medical Technology (USA)
Aseptica (USA)
Golden Bridge Internatonal (USA)

11:30-12:45
Lunch (Saito Bio-hills Cafe)

13:00-15:00
Individual Meeting between Companies



2009-1-30 (Friday):
The Senri Life Science Seminar "Topics: Emerging and Reemerging Infectious Diseases"


Recently, emerging and reemerging infectious diseases such as avian influenza, SARS, BSE, and drug resistant bacteria infection have brought various influences to our country and the world. In this seminar the following presentations are scheduled:

1) Three recent study results brought the major breakthrough to essential understanding of the infection phenomenon.
2) Three hot topics concerning the diagnosis, prevention, and treatments of the infectious diseases.

Coordinator:
Taroh Kinoshita, Prof. of Immunology Frontier Research Center(IFReC) Osaka Univ. and
Yoshiyuki Nagai, Principal Investigator of Center of Research Network for Infectious Diseases (CRNID) RIKEN

Schedule:10:00-17:00 Friday, Jan.30, 2009
Place:Life Hall at Senri Life Science Center (5F)
Registration fee: Free(300 capacity)
e-mail: tkd@senri-life.or.jp


==================================
Agenda
Programs Speaker
Overview: Yoshiyuki Nagai (Principal Investigator, IFReC Osaka Univ.)
New herpes simplex infection mechanism through paired receptor PILR Hisashi Arase (Principal Investigator IFReC Osaka Univ.)
A molecular basis of bacteria multidrug resistance: Structure and function of multidrug efflux transporterAkihito Yamaguchi (Professor, Institute of Scientific and Industrial Research (ISIR), Osaka Univ.)
The forefront of influenza researchYoshihiro Kawaoka (Director, International Research Center for Infectious Diseases, Institute of Medical Science, Tokyo Univ.)
Technical innovation for pathogen gene detection resulting from "the Emerging and Reemerging Infectious Diseases Research Program".Yoshiko Okamoto (Information Section, CRNID RIKEN)
New anti-influenza drug T-705Yosuke Furuta (Department of Business Development, TOYAMA CHEMICAL CO., LTD)
The international collaboration for AIDS vaccine development started by the Sendai Vector ProjectTetsuro Matano (Professor, International Research Center for Infectious Diseases, Institute of Medical Science, Tokyo Univ.) andMamoru Hasegawa, (CEO, DNAVEC Corporation)
General discussion:Taroh Kinoshita (Professor, IFReC Osaka Univ.)
Closing remarks:Taroh Kinoshita (Professor, IFReC Osaka Univ.)



2009-1-9 (Friday):
The Senri Life Science Seminar "Stem Cell and Pluripotency"


Prof. Yamanaka reported on the establishment of human iPS cell line on Nov. 2007. For this worldwide discovery Japanese government decided the research support with exceptional speed, and held the symposium of iPS at the end of last year. Subsequently, the research on iPS cell has accelerated from various angles all over the world. In fact, the session of iPS attracts the most a lot of audiences in any conference on the stem cell.

  This seminar is held in year about first from the Yamanaka's report, so it would be valuable for similar members of the JST Symposium 2007 including Prof. Yamanaka to look back on what has been elucidated in this one year.

  In this Seminar they will discuss freely about what can be done, what has not been realized, what kind of researches has been conducting in the world, what is the future as a result, and what is the problem to Japan generating this technology.

Coordinator: Shinichi Nishikawa, Deputy Director, Center for Developmental Biology (CDB) RIKEN

Schedule:10:00-16:50 Friday, January 9, 2009
Place:Life Hall at Senri Life Science Center (5F)
Registration fee: Free
e-mail: sng@senri-life.or.jp


==================================
Agenda
[Pluripotency and Reprogramming]
Overview : The roots of iPS cell researchShinichi Nishikawa (Deputy Director, CDB RIKEN)
The basic frame of transcription factor network regulating pluripotencyHitoshi Niwa (Team Leader, CDB RIKEN)
Possibility and problem of iPS cellShinya Yamanaka (Director, Center for iPS Cell Research and Application (CiRA), Kyoto University)
[Problems from translational research to clinical application]
Stem cell and retina regenerationMasayo Takahashi (Team Leader, CDB RIKEN)
Nerve regeneration strategy using iPS cellHideyuki Okano (Professor, Department of Physiology, Keio University School of Medicine)
Evaluation of effectiveness and safety for clinical application of iPS cell Yutaka Hanazono (Professor, Center for Molecular Medicine, Jichi Medical University)
[Summary and perspective]
The future of stem-cell researchShinichi Nishikawa (Deputy Director, CDB RIKEN)



2008-12-10 (Wednesday):
The 44th MTR Seminar "Customization of Extracellular Matrix and Matrixome " by Dr.Kiyotoshi Sekiguchi, Professor of the Institute for Protein Research Osaka University.


The cell proliferation and differentiation are regulated by various information released from the surrounding environment. The players bearing such information are the extracellular matrix and humoral factors secreted from the neighboring cells.

The lecturer has focused on the basement membrane as a scaffold closely available for most cells, and comprehensively analyzed the localization of almost all known basement membrane proteins using the immunohistochemical method.

In this seminar, he will introduce the molecular entity of extracellular matrix clarified through his recent analysis, focusing especially on molecular composition of the basement membrane and its spatiotemporal control customized for each cell. In addition, he will discuss its significance in the regenerative medicine.

Date: 18:00-19:00, December 10, 2008
Place: Osaka University Medical School, Lecture hall A



2008-12-04 (Thursday):
SAITO-NIBIO(National Institute of Biomedical Innovation) Collaborated Forum


Schedule: December 4 (Thu)-5(Fri), 2008
Place: Yomiuri-Bunka Hall (Osaka Japan)
Registration fee: Free


==================================
Agenda (December 4, 2008)
10:00-10:10 Welcome and introduction
10:10-11:10 Special lecture: The possibility and problem of Pluripotent Stem Cells (iPS Cells)
Shinya Yamanaka (Professor, Director General, iPS Cells Research Center, Kyoto University)
[Research reports from NIBIO]
11:10-11:40 Search for biomarkers for safety evaluation and their perspective in toxicogenomics informatics project
Hiroshi Yamada(Sub Leader of toxicogenomics informatics project, NIBIO)
11:40-12:10 Human ES-cell culture method as a tool for drug discovery
Miho Furue (Kusuda ) (Researcher, Department of Biomedical Resources, NIBIO)
12:10-13:10 Lunch time
[Reports from basic research promotion program of NIBIO in health and medical treatment fields, 2008]
13:10-14:00 Development of a new drug that overcomes multidrug-resistant bacterium infectious disease
Akito Yamaguchi (Professor, Institute of Scientific and Industrial Research, Osaka University)
14:00-14:40 Development of new diagnostics and treatment / preventive methods for liver disease aiming at TGF-beta activation pathway
Soichi Kojima (Leader of Molecular Ligand Target Research Team, RIKEN)
14:40-15:20 Research on antimicrobial peptide AG-30 for application to wound healing
Katsuto Tamai (Associate professor, Osaka University Graduate School of Medicine and Faculty of Medicine)
15:20-15:40 Coffee break
15:40-16:20 Development of new treatment for malignant mesothelioma caused by asbestos exposure based on molecular biology
Ikuo Morimoto (Professor, Institute of Medical Science, University of Tokyo)
16:20-17:00 Development of fundamental treatment method against degenerative disorder of the nervous / muscular system by autologous cell transplantation
Mari Dezawa (Professor, Tohoku University Graduate School of Medicine and Faculty of Medicine)
17:30-19:00 Welcome Reception at Senri Hankyu Hotel (Fee: 2000yen)



==================================
Agenda (December 5, 2008)
10:00-10:45 Keynote lecture: Approach of PMDA toward promotion for innovative drug development
Satoshi Toyoshima (Executive Director of Center for Product Evaluation, Pharmaceuticals and Medical Devices Agency)
[Toward innovative drug discovery]
10:45-11:05 The Drug Discovery Value Chain (a trial of innovative drug discovery)
Tsuneaki Sakata (Guest Professor, Osaka University Cyber Media Center)
11:05-11:15 SOSHO project: Development of new crystallization technology and its application example
Tsuyoshi Inoue (Professor, Osaka University Graduate School of Engineering)
11:15-11:25 Drug discovery research using high throughput X-ray structure analysis
Kensaku Hamada (Board Director, PharmAxess Inc.)
11:25-11:35 Technical supports provided by Saito Proteomics Analysis Center
Hiroyuki Fukuda (Director of Proteomics Analysis Center, Theravalues Corporation)
11:35-11:45 Chemical synthesis of bioactive peptides and their disulphide structure determination
Yuji Nishiuchi (Research Manager of Peptide Institute, Inc., and Guest Professor of Osaka University Graduate School of Science)
11:45-11:55 The use of high magnetic field NMR-LC/MS system and its capability
Kenichi Akagi (Researcher, Bio-resources Research Division, NIBIO))
11:55-12:00 Summary
Tsuneaki Sakata (Guest Professor, Osaka University Cyber Media Center)
12:10-13:10 Lunch time
[Vaccine Forum]
13:10-13:50 Mucosal immunity as vaccine target
Hiroshi Seino (Professor, Institute of Medical Science, University of Tokyo)
13:50-14:20 A report from vaccine investigation committee (after visit to Europe)
Atsushi Kurata (Director, Toyama Institute of Public Health)
14:20-14:30 Coffee break
14:30-15:15 Preventive vaccine against carcinogenic human papillomavirus infection
Tadahito Kanda (Director of Infectious Disease Surveillance Center, National Institute of Infectious Diseases)
15:15-16:00 Development of molecular adjuvant targetting TLR
Ken Ishii (Associate professor, Research Institute for Microbial Diseases, Osaka University)
16:00-16:45 Current status and future perspective of vaccine for animal
Hideto Sekiguchi (Section Leader, the National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries)
16:45-16:50 Closing remarks
Koichi Yamanishi (Director General, National Institute of Biomedical Innovation)



2008-11-17 (Monday):
Opening Ceremony of "Saito Bio-innovation Center"


The Opening Ceremony of "Saito Bio-innovation Center" will be held according to the following. In the Saito Life Science Park, two incubation facilities have been operated for bio-ventures so far, and the third incubator has been anticipated because of their full occupancy state. All the facilities including "Saito Bio-innovation Center" have already become full, and 35 venture companies related to biotechnology are now advancing their research and development.

Opening ceremony

Date : 11:30-14:00 Monday, November 17
Place: Saito Bio-innovation Center

==================================
Agenda:
--Opening Greeting: Masahiro Maeda, Chief Director of "the Organization for Small & Medium Enterprises and Regional Innovation, JAPAN" (SMRJ)
--Ribbon cutting
--Guests' Greetings:
1) Tomofumi Hiraku, Director of the Kansai Bureau of Economy, Trade and Industry (METI-KANSAI)
2) Toru Hashimoto, Governor of Osaka Prefecture
3) Senichi Nomura, Mayer of Ibaraki City
4 )Masayoshi Tani, Chairman & CEO of Bio-Sight Capital



2008-11-04 (Tuesday):
Special seminar "New development of stem cells derived from fat tissue" by Dr. Akifumi Matsuyama, Associate Professor of MTR (Medical Center for Translational Research, Osaka University Hospital)


NIBIO (National Institute of Biomedical Innovation) will invite Dr. Akifumi Matsuyama, Associate Professor of MTR (Medical Center for Translational Research, Osaka University Hospital), and hold a special seminar. Dr. Matsuyama found polyphyletic progenitor cells as new stem cells from fat tissue that can be harvested easily and safely. The new stem cells are characterized by expression of Isl-1, a non-differentiation marker, and have ability to differentiate not only into bone, cartilage, fat tissue, but also into cardiac myoblasts, hepatic cells, insulin-secreting cells. Additionally, these new stem cells partially express c-myc, oct3/4, Klf4 and nanog.
Please participate by all means since the application of such new stem cells are expected very much for development toward regenerative therapy and drug discovery screening.

Date : 16:00-17:00 Tuesday, November 4
Place: National Institute of Biomedical Innovation (NIBIO), 1F
Participation fee: Free (80 capacity)
Sponsor: NIBIO



2008-08-26 (Tuesday):
Special lecture "Structural Biology, Bioinformatics and Drug Discovery: new approaches to exploring biological and chemical space" by Sir Tom Blundell, Professor of the University of Cambridge.


Professor Sir Tom Blundell is not only an authority in the drug discovery field based on structural biology and informatics, but also holds prominent positions of the government agency such as the Chief Executive of BBSRC (http://www.bbsrc.ac.uk/) and the Chairman of the Royal Environmental Pollution Committee. So he is one of the famous scientists in UK. Please participate by all means because it is a valuable chance that you can learn the research trend of the cutting edge concerning structural biology and the insilico drug discovery.

Date: 16:00-17:00 Tuesday, August 26
Place: National Institute of Biomedical Innovation (NIBIO), 1F
Participation fee: Free
Sponsor: NIBIO
Get-together meeting: Held after the lecture (fee: 2000yen)



2008-08-22 (Friday):
Special lecture "Latest Trend of Biotechnology Cluster" by Steve Collins, Associate Professor of University of Washington, US


The associate professor Collins specializes in the research of politics and the science & technology policy, and is currently doing a comparative study on the biotechnology cluster in the world from the policy side. He is especially well informed about the biotechnology cluster circumstances of the United States and Japan, and the main includes a comparison research on the biotechnology cluster of Kobe and its sister city Seattle where University of Washington locates, and a study on Research Triangle Park in North Carolina, etc.
Because he speaks Japanese a little, the chance of the question and answer is scheduled, though Nagao, associate professor of Osaka City University Graduate School Economics, interprets in the lecture. Please participate by all means since it is a valuable chance that you can learn latest trend of the biotechnology cluster in the world.

Date: 16:00-17:30, Friday, August 22, 2008
Place: National Institute of Biomedical Innovation (NIBIO), 1F
(http://www.nibio.go.jp/introduction/access.html)
Participation fee: Free